How To Get To Florida Keys From NYC? – Fly from New York JFK (JFK) to Miami (MIA) JFK – MIA. – Take a shuttle bus from Miami, FL – International Airport to Big Pine Key, FL. What is the closest major airport to Key West Florida? The closest major airport to Key West, Florida is Key West International Airport (EYW / KEYW). This airport is 2 miles from the center of Key West, FL. Is driving to the Keys worth it? The drive to Key WestKey WestKey West (Spanish: Cayo Hueso) is an island in the Straits of Florida, within the U.S. state of Florida. Together with all or…